洪羽屏 Yu-Ping Hong

My research interest field is in bacterial drug resistance and infectious pathogens. I specialize in utilizing NGS (Next-Generation Sequencing) technology to study antimicrobial resistance mechanisms, bacteria molecular typing, and mNGS application in infectious diseases.

專利檢索工程師

1. “藉由固相吸附富集微生物核酸以鑑定微生物及/或抗藥基因的檢測系統”新型專利(M642197，專利期限：2023-06-11至2032-06-06)

2. “藉由固相吸附富集微生物核酸與鑑定微生物及/或抗藥基因的檢測系統及方法”，台灣發明專利(審查中)

3. “METHODS FOR ENRICHING MICROBIAL NUCLEIC ACIDS BY IMMOBILIZED ADSORPTION”，美國臨時案

4. “DIAGNOSTIC SYSTEMS AND METHODS FOR THE ENMCHMENT OF MICROBIAL NUCLEIC ACIDS AND THE IDENTIFICATION OF 

5. “MICROORGAMSMS AND/OR RESISTANCE GENES BY IMMOBILIZED ADSORPTION”，美國發明專利(審查中)

6. “快速鑑定微生物與抗藥性的檢測系統”技術移轉案，2023

1. 署內科技研究計畫“整合與提升我國食媒性疾病及其病原監測防護網計畫” (2016-2017)

2. 署內研究計畫“建置抗藥性微生物檢測實驗室與巨量資料庫應用系統” (2017-2020)

3. 署內研究計畫“即時人畜共通病原可攜式檢測平台開發” (2021-2024)

4. 科發基金優先計畫”快速病原及抗藥基因鑑定平台”(Rapid pathogen and drug resistance gene identification system)(2023/05-2024/04)

1. Poster display "Building a pan-genome allele database for whole genome sequence-based

genotyping of Salmonella isolates of more than 250 serovars", 2018 ASM Conference on Rapid Applied Microbial Next-

Generation Sequencing and Bioinformatic Pipelines， (2018/9/23-2018/9/26)

2. Poster display "RamAp promotes antimicrobial resistance and potentially affects the expression of virulence-related genes in Salmonella", 2022第45屆日本生物學會年會(MBSJ2022)，(2022/11/30-2022/12/2) ，

3. Genomic Surveillance and Data Sharing in Asia and the Asia Pacific Regions – Panel Discussion, 2023第13屆Global Microbial Identifier (GMI13)會議，加拿大溫哥華(2023/9/13-2023/9/15)

4. 2023 PulseNet International (PNI) meeting，加拿大溫哥華，(2023/9/15-2023/9/16)

1. Hong YP, Chen BH, Wang YW, Teng RH, Chen YS, Wei HL, Chiou CS. The usefulness

 of Nanopore Sequencing in Whole-Genome Sequencing-Based Genotyping of Listeria 

monocytogenes and Salmonella enterica serovar Enteritidis. bioRxiv 2023 doi: 

10.1101/2024.01.29.577746

2. Hong YP, Chen YT, Wang YW, Chen BH, Teng RH, Chen YS, Chiou CS. Integrative

and Conjugative Element-Mediated Azithromycin Resistance in Multidrug-Resistant

Salmonella enterica serovar Albany. Antimicrob Agents Chemother. 2023 May

1;65(5):e02634-20. doi: 10.1128/AAC.02634-20. Epub 2021 Mar 8. PMID: 33685895;

PMCID: PMC8092877.

3. Hong YP, Wang YW, Chen BH, Song HY, Chiou CS, Chen YT. RamAp Is an Efflux

Pump Regulator Carried by an IncHI2 Plasmid. Antimicrob Agents Chemother. 2022

Jan 18;66(1):e0115221. doi: 10.1128/AAC.01152-21. Epub 2021 Oct 25. PMID:

34694885; PMCID: PMC8765224.

4. Hong YP, Wang YW, Huang IH, Liao YC, Kuo HC, Liu YY, Tu YH, Chen BH, Liao

YS, Chiou CS. Genetic Relationships among Multidrug-Resistant Salmonella

enterica Serovar Typhimurium Strains from Humans and Animals. Antimicrob Agents

Chemother. 2018 Apr 26;62(5):e00213-18. doi: 10.1128/AAC.00213-18. PMID:

29581119; PMCID: PMC5923113.

5. Hsu P-C, Wang Y-W, Chen B-H, Hong Y-P, Teng R-H, Liu P-Y, Chiou C-S.

Carbapenem resistance in extensively drug-resistant Salmonella enterica

serovar Agona and AmpC β-lactamase-producing S. Infantis. Microbiol

Spectr. 2023 Dec 12;11(6):e0292223. doi: 10.1128/spectrum.02922-23. Epub 2023

Oct 3. PMID: 37787563; PMCID: PMC10714929.

6. Chiou CS, Chen BH, Lauderdale TL, Hong YP, Teng RH, Liao YS, Wang YW, Chang

JH, Liang SY, Tsao CS, Wei HL. Epidemiological trends and antimicrobial

resistance in Salmonella enterica serovar Typhimurium clones in Taiwan between

2004 and 2019. J Glob Antimicrob Resist. 2023 Dec;35:128-136. doi:

10.1016/j.jgar.2023.09.005. Epub 2023 Sep 13. PMID: 37709137.

7. Liao YS, Wei HL, Kuo HC, Chen BH, Wang YW, Teng RH, Hong YP, Chang JH, Liang

SY, Tsao CS, Chiou CS. Chromosome-Borne CTX-M-65 Extended-Spectrum β-Lactamase-Producing Salmonella enterica Serovar Infantis, Taiwan. Emerg Infect Dis. 2023 Aug;29(8):1634-1637. doi: 10.3201/eid2908.230472. PMID: 37486207; PMCID:

PMC10370839.

8. Chiou CS, Hong YP, Wang YW, Chen BH, Teng RH, Song HY, Liao YS. Antimicrobial

Resistance and Mechanisms of Azithromycin Resistance in Nontyphoidal Salmonella

Isolates in Taiwan, 2017 to 2018. Microbiol Spectr. 2023 Feb 14;11(1):e0336422.

doi: 10.1128/spectrum.03364-22. Epub 2023 Jan 23. PMID: 36688703; PMCID:

PMC9927516.

9. Chiou CS, Liao YS, Chen BH, Lu MC, Hong YP, Wang YW, Teng RH. Demographic

Features of Invasive Meningococcal Disease in Taiwan, 1993 to 2020, and Genetic

Characteristics of Neisseria meningitidis Isolates, 2003 to 2020. Microbiol

Spectr. 2022 Aug 31;10(4):e0088222. doi: 10.1128/spectrum.00882-22. Epub 2022

Jul 11. PMID: 35862973; PMCID: PMC9430714.

10. Chen YS, Tu YH, Chen BH, Liu YY, Hong YP, Teng RH, Wang YW, Chiou CS.

cgMLST@Taiwan: A web service platform for Vibrio cholerae cgMLST profiling and

global strain tracking. J Microbiol Immunol Infect. 2022 Feb;55(1):102-106. doi:

10.1016/j.jmii.2020.12.007. Epub 2021 Jan 15. PMID: 33485793.

11. Liao YS, Chen BH, Teng RH, Wang YW, Chang JH, Liang SY, Tsao CS, Hong YP,

Sung HY, Chiou CS. Antimicrobial Resistance in Campylobacter coli and

Campylobacter jejuni from Human Campylobacteriosis in Taiwan, 2016 to 2019.

Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0173621. doi:

10.1128/AAC.01736-21. Epub 2021 Nov 8. PMID: 34748382; PMCID: PMC8765299.

12. Chiu PJ, Rathod J, Hong YP, Tsai PJ, Hung YP, Ko WC, Chen JW, Paredes-Sabja

D, Huang IH. Clostridioides difficile spores stimulate inflammatory cytokine

responses and induce cytotoxicity in macrophages. Anaerobe. 2021 Aug;70:102381.

doi: 10.1016/j.anaerobe.2021.102381. Epub 2021 May 31. PMID: 34082120.

13. Liu PY, Wang KC, Hong YP, Chen BH, Shi ZY, Chiou CS. The first imported case

of extensively drug-resistant Salmonella enterica serotype Typhi infection in

Taiwan and the antimicrobial therapy. J Microbiol Immunol Infect. 2021

Aug;54(4):740-744. doi: 10.1016/j.jmii.2020.03.017. Epub 2020 Mar 25. PMID:

32253142.

14. Lu MC, Chen YT, Tang HL, Liu YY, Chen BH, Wang YW, Chen YS, Teng RH, Hong

YP, Chiou CS, Chiang MK, Lai YC. Transmission and evolution of OXA-48-producing

Klebsiella pneumoniae ST11 in a single hospital in Taiwan. J Antimicrob

Chemother. 2020 Feb 1;75(2):318-326. doi: 10.1093/jac/dkz431. PMID: 31665400.

15. Tu YH, Chen BH, Hong YP, Liao YS, Chen YS, Liu YY, Teng RH, Wang YW, Chiou

CS. Emergence of Vibrio cholerae O1 Sequence Type 75 in Taiwan. Emerg Infect

Dis. 2020 Jan;26(1):164-166. doi: 10.3201/eid2601.190934. PMID: 31855545; PMCID:

PMC6924918.

16. Liao YS, Chen BH, Hong YP, Teng RH, Wang YW, Liang SY, Liu YY, Tu YH, Chen

YS, Chang JH, Tsao CS, Chiou CS. Emergence of Multidrug-Resistant Salmonella

enterica Serovar Goldcoast Strains in Taiwan and International Spread of the

ST358 Clone. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e01122-19. doi:

10.1128/AAC.01122-19. PMID: 31383653; PMCID: PMC6761502.

17. Chiou CS, Hong YP, Liao YS, Wang YW, Tu YH, Chen BH, Chen YS. New Multidrug-

Resistant Salmonella enterica Serovar Anatum Clone, Taiwan, 2015-2017. Emerg

Infect Dis. 2019 Jan;25(1):144-147. doi: 10.3201/eid2501.181103. PMID: 30561315;

PMCID: PMC6302611.

18. Chiou CS, Chen YT, Wang YW, Liu YY, Kuo HC, Tu YH, Lin AC, Liao YS, Hong YP.

Dissemination of mcr-1-Carrying Plasmids among Colistin-Resistant

Salmonella Strains from Humans and Food-Producing Animals in Taiwan. Antimicrob

Agents Chemother. 2017 Jun 27;61(7):e00338-17. doi: 10.1128/AAC.00338-17. PMID:

28416545; PMCID: PMC5487637.