Summary
Overview
Work History
Education
Skills
Certification
Publications
Recognition
Software
Timeline
Generic
Wu Yueh Chin

Wu Yueh Chin

Scientist
Xizhi Dist.

Summary

Scientist with proven track record in conducting innovative research and contributing to scientific advancements. Known for collaborative teamwork and achieving results in dynamic environments. Skilled in experimental design and data interpretation, ensuring high standards and reliability in all projects.

Overview

11
11
years of professional experience
1
1
Certification
1
1
Language

Work History

Scientist III

OBI pharma Inc.
04.2025 - Current
  • Designed and supported GLP/non-GLP toxicology studies (e.g., dose range-finding, repeat-dose, safety pharmacology) for IND/CTA submissions.
  • Ensured study compliance with global regulatory standards (ICH, FDA, EMA, NMPA).
  • Coordinated with CROs on study protocols, timelines, and in-life monitoring for rodent and non-rodent models.
  • Interpreted toxicological data, integrating clinical, pathological, and bioanalytical findings.
  • Contributed to study reports, nonclinical summaries, and Module 4 sections for regulatory filings.
  • Collaborated with pharmacology, DMPK, and CMC teams to evaluate safety and support FIH dosing decisions.
  • Assisted in the investigation and risk assessment of unexpected toxicities.

Scientist II / Project manager

OBI pharma Inc.
03.2017 - 03.2025
  • Developed drug discovery strategies, managed timelines, and coordinated cross-functional communication.
  • Assessed and recommended CROs for preclinical and in vitro studies.
  • Monitored project progress, identified risks, and implemented mitigation plans to ensure timely delivery.
  • Reported project updates to senior management and aligned with functional teams.
  • Designed and validated in vitro assays (e.g., ELISA, cytotoxicity, internalization, cytokine release, ADCC, ADCP) for small molecules, antibodies, and ADCs.
  • Contributed to the preparation of IND submission documents (Modules 2 and 4).

Scientist I

OBI pharma Inc.
08.2014 - 03.2025
  • Developed analytical methods and established product specifications for botulinum toxin in accordance with PIC/S and cGMP guidelines.
  • Designed and optimized manufacturing processes, including production and cleaning procedures, for botulinum toxin.
  • Planned and executed formulation development and stability studies to support product shelf life and regulatory requirements.
  • Managed contract research organizations (CROs) for preclinical animal studies, ensuring study quality and compliance.
  • Established and validated Master Cell Bank (MCB) and Working Cell Bank (WCB) systems for production consistency and traceability.
  • Led the implementation of the CWA 15793 bio risk management system to fulfill Taiwan CDC regulatory requirements.
  • Oversaw the biosafety and biosecurity management of OBI-858, ensuring compliance during Taiwan CDC inspections.

Education

M.S. - Biological science & tech.

National Chiao Tung University

B.S. - Microbiology

Soochow University

Skills

Research and experiment design

Certification

PMP certification, Project Management Institute, 1548656

Publications

  • Ting-Yu Chang, Chun-Jung Lin, Shih-Ni Wen, Yi-Chen Wu, Cheng-Yen Wei, Jye-Yu Huang, Yu-Hsuan Tsao, Yu-Jung Chen, Wei-Chien Tang, Yuen-Chin Wu, Wei-Han Lee, Teng-Yi Huang, Tzer-Min Kuo, Wan-Fen Li, Ming-Tain Lai, Preclinical evaluation of a novel antibody–drug conjugate OBI-992 for Cancer therapy, Scientific Reports, 2025, 15, 8735, https://www.nature.com/srep
  • Ming-Chen Yang, Chi-Sheng Shia, Wan-Fen Li, Chun-Chung Wang, I-Ju Chen, Teng-Yi Huang, Yu-Jung Chen, Hui-Wen Chang, Chi-Huan Lu, Yueh-Chin Wu, Nan-Hsuan Wang, Jiann-Shiun Lai, Cheng-Der Yu, Ming-Tain Lai, Preclinical Studies of OBI-999: A Novel Globo H–Targeting Antibody–Drug Conjugate, Mol Cancer Ther, 2021
  • Jui-Jen Chang, Feng-Ju Ho, Cheng-Yu Ho, Yueh-Chin Wu, Yu-Han Hou, Chieh-Chen Huang, Ming-Che Shih, Wen-Hsiung Li, Assembling a cellulase cocktail and a cellodextrin transporter into a yeast host for CBP ethanol production, Biotechnol Biofuels, 2013, 6, 19
  • Wang TY, Chen HL, Lu MY, Chen YC, Sung HM, Mao CT, Cho HY, Ke HM, Hwa TY, Ruan SK, Hung KY, Chen CK, Li JY, Wu YC, Chen YH, Chou SP, Tsai YW, Chu TC, Shih CC, Li WH, Shih MC, Functional characterization of cellulases identified from the cow rumen fungus Neocallimastix patriciarum W5 by transcriptomic and secretomic analyses, Biotechnol Biofuels, 2011, 4, 24

Recognition

Importing the CWA 15793 system and award-winning laboratory.

Software

GraphPad Prism

Pymol

Microsoft Project

Timeline

Scientist III

OBI pharma Inc.
04.2025 - Current

Scientist II / Project manager

OBI pharma Inc.
03.2017 - 03.2025

Scientist I

OBI pharma Inc.
08.2014 - 03.2025

B.S. - Microbiology

Soochow University

M.S. - Biological science & tech.

National Chiao Tung University

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